Clarke has always been fascinated with the point where the human departs from the animal and the often transgressive relationship we have with animals throughout history, art, religion and science. Her imagery renders provocative scenes that are at once abject, erotic, seductive and haunting, containing fantastical and occasionally mythological overtones, surreal and ambitious in their strangeness. Since becoming a mother, her work has moved to explore the animalistic abject nature of pregnancy and birth. She uses Intaglio printmaking as a vehicle for the subject mater, with its infinite capacity for detail. Often using delicate hard ground lines to caress the figures, carmine ink to mimic the fleshy tones of meat, and occasionally the bold rich blacks achieved in an etched aquatint.